nagano_imageNahoko NAGANO (Assistant Professor): Diagnostic Pathology, Gastrointestinal Pathology, Cytologic Diagnosis
yoshida_imageKenji YOSHIDA (Associate Professor): Contrast enhanced ultrasound, ultrasound and near infrared fl uorescence du ...

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Ultrasound and near infrared fluorescence dual imaging using nano- and micrbubbles Kenji YOSHIDA Ultrasound and near infrared fluorescent dual imaging have been developed. By a combination of near infrared fluorescent with higher resolution and ultrasound with better penetration depth, we propose an imaging method for visualizing vessels near surface and in deeper tissue. We have developed the contrast agents which can work in both imaging methods, in particular, fluorescent nanobubbles for imaging of lympha system(lympha vessels and lympha nodes). Nanobubbles based on liposome have internal gas as ultrasound contrast agents and indocyanine green derivatives is supported to the lipid bilayer membrane. The ability of contrast agents could be confirmed by using clinical equipment.